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Alan van Giessen uses theoretical and computational techniques to understand the structure and thermodynamics of both complex and simple systems. His research focus has focused on the destabilization of a test protein and its potential to provide a mechanism for nucleating misfolded aggregates complicit in diseases such as Alzheimer’s Disease and Huntington's Disease. A second area of focus is the energetic properties of curved interfaces, such as liquid drops or micelles. Van Giessen teaches a wide range of courses including both general chemistry and physical chemistry and including a seminar course entitled “Poisons: Death by Chemistry”.